Thierry Henry, Robert Pires, Jose Reyes and Sol Campbell are all expected to be rested, giving Portsmouth, who really gave the Londoners a game at Highbury earlier this season, a strong chance of getting something from the game.
Out of form Kanu will partner young but dangerous Jeremie Alidiere in attack.
Meanwhile, John Curtis and Lomano Lua Lua are cup tied, whilst Teddy Sheringham, Hayden Foxe, Dejan Stefanovic and Patrik Berger all miss out.
Steve Stone and possibly Svetoslav Todorov are expected to make their return from injury as Portsmouth aim for glory.